A patient with an intracranial hemorrhage can look surprisingly stable…until they suddenly don’t. Recognizing the subtle signs of rising intracranial pressure before herniation occurs is one of the most time-critical skills in emergency medicine. In this episode, Drs. James Nardini, Mike Prats, and Kim Bambach discuss a practical, evidence-based approach to critical brain resuscitation, from recognizing early deterioration to implementing tiered ICP management, choosing hyperosmolar therapy, optimizing sedation, and avoiding common pitfalls. Based on the Emergency Neurological Life Support (ENLS) framework, this episode provides a systematic approach you can apply on your next shift.
Guest: James Nardini, MD, MS; Host: Mike Prats, MD and Kim Bambach, MD; Editor: Kim Bambach, MD
🔑 Key Learning Points
1. Recognize deterioration early
- Elevated ICP often begins with nonspecific symptoms (headache, vomiting, confusion, gait disturbance).
- Serial neurologic examinations are more valuable than a single assessment.
- Track:
- Glasgow Coma Scale (watch for declining scores)
- Pupillary size and reactivity
- New focal neurologic deficits
- Mental status changes
- A >1 mm change in pupil size may be an early sign of herniation.
2. Understand herniation syndromes
- Subfalcine: contralateral leg weakness (ACA compression)
- Uncal (transtentorial):
- ipsilateral fixed dilated pupil
- decreased consciousness
- contralateral hemiparesis
- Tonsillar:
- occipital headache
- neck stiffness
- progressive brainstem compression
- eventual Cushing triad
3. Cushing triad is a late finding
- Hypertension
- Bradycardia
- Irregular respirations
Waiting for the full triad means the patient is already critically decompensating.
4. Follow a tiered approach (Emergency Neurological Life Support)
Tier 0: Optimize physiology
- ABCDE assessment
- Protect airway, maintain oxygenation and ventilation
- Normalize glucose
- Treat fever
- BP management
- Elevate head of bed (when appropriate)
- Provide analgesia and sedation
- Obtain urgent non-contrast head CT
- Minimize secondary brain injur
Tier 1: Temporize while arranging for definitive care
- Hyperosmolar therapy
- Brief controlled hyperventilation if actively herniating
- Early neurosurgical consultation and if needed arrange transfer for neurosurgical consultation. You can advocate for your patient.
5. Hypertonic saline vs. mannitol
- Both improve outcomes and are reasonable first-line agents.
- Hypertonic saline may provide:
- more sustained ICP reduction
- better cerebral perfusion pressure
- superior ICP control in several studies
- Don’t delay treatment simply because one agent is unavailable.
- In selected critically ill patients, both therapies may be used.
6. Monitor sodium carefully
- Obtain a baseline sodium on patient arrival.
- Check sodium frequently after hypertonic saline.
- Typical therapeutic target:
- 145–155 mEq/L
6. Propofol is the preferred sedative
Benefits:
- Decreases cerebral metabolic demand
- Reduces cerebral blood volume
- Lowers ICP
- Suppresses seizures
Watch for:
- Hypotension
- Reduced cerebral perfusion pressure
Maintain adequate blood pressure while sedating.
7. Common pitfalls
A common pitfall is waiting too long to initiate hyperosmolar therapy. If you’re seriously asking whether the patient needs hypertonic therapy, that may be the moment to act rather than waiting for unmistakable herniation.
8. Emergency physicians are the bridge to definitive care
The goal is to:
- Recognize deterioration
- Prevent secondary injury
- Optimize physiology
- Initiate temporizing therapies
- Rapidly connect patients with neurosurgical intervention
9. Ultrasound pearl
Bedside ultrasound may provide additional information:
- optic nerve sheath diameter measurement
- optic disc elevation
- transcranial ultrasound (experienced users)
📚 Further Resources
- Emergency Neurological Life Support Course
- Emergency Neurological Life Support Intracranial Hypertension and Herniation Protocol
- Guidelines for the Acute Treatment of Cerebral Edema in Neurocritical Care Patients- Neuro Critical Care Society
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